梯度浓度孕酮对Aβ1-40损伤的海马神经干细胞增殖的影响
肖韩艳;齐志国;
摘要(Abstract)：
目的:研究神经甾体孕酮(PROG)对Aβ1-40损伤的海马神经干细胞增殖的影响。方法:本研究采用MTT实验获得增殖曲线,检测梯度浓度孕酮对Aβ1-40损伤的海马神经干细胞增殖能力的影响,海马神经干细胞分为空白对照组、损伤对照组及5个浓度PROG处理组。结果:与损伤对照组比较,PROG能剂量依赖地对抗Aβ1-40损伤后引起的大鼠海马来源的神经干细胞存活率的降低,PROG也具有促进Aβ1-40损伤后的大鼠海马来源的神经干细胞增殖的作用。结论:PROG能对抗Aβ1-40损伤后的大鼠海马来源的神经干细胞损伤,促进Aβ1-40损伤后的大鼠海马来源的神经干细胞的增殖和提高其存活能力。
关键词(KeyWords)： 孕酮;β-淀粉样蛋白;神经干细胞;神经毒性;阿尔茨海默病
基金项目(Foundation):
作者(Author): 肖韩艳;齐志国;
Email:
DOI: 10.13799/j.cnki.mdjyxyxb.2014.02.016
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