IL-12与Th17在自身免疫性甲状腺疾病中的研究进展
李娜;连续;
摘要(Abstract)：
自身免疫性甲状腺病(AITD)是由个体遗传背景差异、机体自身免疫功能紊乱和多种外部环境因素联合作用导致的甲状腺疾病,其中机体的免疫功能紊乱是其主要的原因。细胞因子白介素-12(IL-12)家族和辅助性T细胞17(Th17)与AITD关系作为密切,IL-12家族是唯一的异二聚体细胞因子家族,其包括IL-12、IL-23、IL-27和IL-35四个家族成员。Th17是近几年发现的第三个效应T细胞亚群,它是组织炎症的有效诱导剂,在自身免疫性疾病的调节中起着至关重要的作用。IL-12家族和Th17细胞及其相关细胞因子在AITD患者外周血或甲状腺组织中高表达,并在甲状腺疾病的发病过程中起重要作用。本文综述了IL-12家族和Th17细胞因子与AITD关系的最新研究进展,并特别强调了细胞因子调节在AITD治疗中的应用前景。
关键词(KeyWords)： 自身免疫性甲状腺疾病;IL-12家族;Th17细胞
基金项目(Foundation):
作者(Author): 李娜;连续;
Email:
DOI: 10.13799/j.cnki.mdjyxyxb.2020.06.039
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