COX-2与胃癌相关性研究现状
叶春祥;陆睿;
摘要(Abstract)：
环氧化酶-2(COX-2)是环氧化酶的诱导型,是合成前列腺素(PG)过程中一个重要的限速酶。近年来的研究表明,COX-2在肿瘤细胞生长、细胞凋亡和肿瘤血管生成方面发挥重要作用。本为拟就COX-2与胃癌的关系研究现状作一综述。
关键词(KeyWords)： COX-2;胃癌
基金项目(Foundation):
作者(Author): 叶春祥;陆睿;
Email:
DOI: 10.13799/j.cnki.mdjyxyxb.2009.03.059
参考文献(References)：
- 1 MTakeichi.Cadherin cell adhesion receptors as a morphogenetic reg-ulator[J].Science,1991,251(22):1451-1455.
- 2 Kinoshita T,Takahashi Y,Sakashita T,et al.Growth stimulation andinduction of epidermal growth factor receptor by over expression of cy-clooxygenase 1 and 2 in human colon carcinoma cells[J].Biochimicaet BiophsicaActa,1999,1438(1):120-130.
- 3 Chang YW,Cho HL,Jang JY,et al.Role of cyclooxygenase-2(COX-2)and peroxisome proliferator-activated receptor(PPAR)in gas-tric cancer.Korean Journal of Gastroenterology[J].2004,43(5):291-8.
- 4 Chen XL,Su BS,Sun RQ,et al.Relationship between expression anddistribution of cyclooxygenase-2 and bcl-2 in human gastric adeno-carcinoma[J].World Journal of Gastroenterology.2005,11(8):1228-31.
- 5 Sun WH,Yu Q,Shen H,et al.Roles of Helicobacter pylori infectionand cyclooxygenase-2 expression in gastric carcinogenesis[J].WorldJournal of Gastroenterology.2004,10(19):2809-13.
- 6 Fu S,Ramanujam KS,Wong A,et al.Increased expression and cellu-lar localization of inducible nitricoxide synthase and cyclooxygenase 2in Helicobacter pylori gastritis[J].Gastroenterology,1999,116(6):1319-1329.
- 7 Konturek SJ,Konturek PC,Hartwich A,et al.Helicobacter pylori in-fection and gastrin and cyclooxygenase expression in gastric and color-ectal malignancies[J].Regul Pept,2000,93(1-3):13-19.
- 8 Sheu BS,Yang HB,Sheu SM,et al.Higher gastric cycloxygenase-2expression and precancerous change in Helicobacter pylori-infectedrelatives of gastric cancer patients[J].Clinical Cancer Re-search.2003,9(14):5245-51.
- 9 Mao XY,Wang XG,Lv XJ,et al.COX-2 expression in gastric cancerand its relationship with angiogenesis using tissue microarray[J].World Journal of Gastroenterology.2007,13(25):3466-71.
- 10 Fu YG,Sung JJ,Wu KC,et al.Inhibition of gastric cancer-associat-ed angiogenesis by antisense COX-2 transfectants[J].Cancer Let-ters,2005,224(2):243-52.
- 11 Mrena J,Wiksten JP,Thiel A,et al.Cyclooxygenase-2 is an inde-pendent prognostic factor in gastric cancer and its expression is regu-lated by the messenger RNA stability factor HuR[J].Clinical Canc-er Research.2005,11(20):7362-8.
- 12 Thun MJ,NamboodiriMM,Calle EE,et al.Aspirin use and risk of fa-tal cancer[J].Cancer Res,1993,53(6):1322-1327.
- 13 Yu J,Tang BD,Leung WK.Different cell kinetic changes in ratstomach cancer after treatment with celecoxib or indomethacin:im-plications on chemoprevention[J].World J Gastroenterol,2005,11(1):41-5.
- 14 Kapp JA,Kapp LM,McKenna KC,et al.gamma delta T-cell clonesfrom intestinal intraepithelial lymphocytes inhibit development ofCTL responses ex vivo.Immunology,2004,111:155-164.
- 15 Fu SL,Wu YL,Zhang YP,et al.Anti-cancer effects of COX-2 in-hibitors and their correlation with angiogenesis and invasion in gas-tric cancer[J].World Journal of Gastroenterology,2004,10(13):1971-1974.