肺癌患者SCC、CYFRA211、NSE和CEA检测的临床意义CLINICAL DIAGNOSTIC SIGNIFICANCE OF SCC,CYFRA211,NSE AND CEA FOR LUNG CANCER
魏善和;朱召明;闫丽妲;邓芳;吴丽;
摘要(Abstract)：
目的:探讨血清肿瘤标记物鳞状细胞癌相关抗原(SCC-Ag)、细胞角蛋白19血清片段211(CYFRA211)、神经元特异性烯醇化酶(NSE),癌胚抗原(CEA)在肺癌临床诊断中的价值。方法:采用酶联免疫法检测109例肺癌病人及48例肺良性病变病人血清SCC-Ag,CYFRA2ll和NSE的水平,化学发光法测定CEA的水平。结果:肺癌组血清四项肿瘤标记物的含量均高于肺良性病变组(P<0.01),SCC水平在肺鳞癌中明显升高;CYFRA211水平以非小细胞肺癌(NSCLC)升高明显;NSE以小细胞肺癌(SCLC)升高为明显;CEA以肺腺癌增高为主;SCC,CYFRA211,NSE,CEA及四项联合检测诊断肺癌的灵敏度分别49.5%,45.9%,56.9%,21.1%。结论:SCC对鳞癌、CYFRA211对非小细胞肺癌(NSCLC),NSE对小细胞肺癌(SCLC),CEA对腺癌具有较大的辅助诊断价值,四项联合检测提高肺癌诊断的灵敏度、准确率。
关键词(KeyWords)： 鳞状细胞癌相关抗原;细胞角蛋白19血清片段211;神经元特异性烯醇化酶;癌胚抗原;肺癌
基金项目(Foundation):
作者(Author): 魏善和;朱召明;闫丽妲;邓芳;吴丽;
Email:
DOI: 10.13799/j.cnki.mdjyxyxb.2010.01.043
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