肺癌患者SCC、CYFRA211、NSE和CEA检测的临床意义CLINICAL DIAGNOSTIC SIGNIFICANCE OF SCC,CYFRA211,NSE AND CEA FOR LUNG CANCER
魏善和;朱召明;闫丽妲;邓芳;吴丽;
摘要(Abstract)：
目的:探讨血清肿瘤标记物鳞状细胞癌相关抗原(SCC-Ag)、细胞角蛋白19血清片段211(CYFRA211)、神经元特异性烯醇化酶(NSE),癌胚抗原(CEA)在肺癌临床诊断中的价值。方法:采用酶联免疫法检测109例肺癌病人及48例肺良性病变病人血清SCC-Ag,CYFRA2ll和NSE的水平,化学发光法测定CEA的水平。结果:肺癌组血清四项肿瘤标记物的含量均高于肺良性病变组(P<0.01),SCC水平在肺鳞癌中明显升高;CYFRA211水平以非小细胞肺癌(NSCLC)升高明显;NSE以小细胞肺癌(SCLC)升高为明显;CEA以肺腺癌增高为主;SCC,CYFRA211,NSE,CEA及四项联合检测诊断肺癌的灵敏度分别49.5%,45.9%,56.9%,21.1%。结论:SCC对鳞癌、CYFRA211对非小细胞肺癌(NSCLC),NSE对小细胞肺癌(SCLC),CEA对腺癌具有较大的辅助诊断价值,四项联合检测提高肺癌诊断的灵敏度、准确率。
关键词(KeyWords)： 鳞状细胞癌相关抗原;细胞角蛋白19血清片段211;神经元特异性烯醇化酶;癌胚抗原;肺癌
基金项目(Foundation):
作者(Author): 魏善和;朱召明;闫丽妲;邓芳;吴丽;
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参考文献(References)：
- 1李宣海.肿瘤标志物的检测与临床[M].北京:人民卫生出版社,1997:226
- 2Buccheri G,Torehio P,Ferrigno D.Clincal equivalence of two cytok-eratin markers in non-small cell lung cancer.Astudy of tissue poly-peptide antigen and cytokeratin19fragments[J].Chest2003,124(2):622-626.
- 3李湘荣,段小平.血清CEA与CYRA211检测对肺癌诊断价值的探讨[J].中国血液流变学杂志,2005,15(2):278-279.
- 4Sarkaria IS,Stojadinovic A,Talbot SG.Squamous cell carcinoma-related oncogene is highly expressed in developing,normal,and ade-nomatous adrenal tissue but not in aggressive adrenocortical carcino-mas[J].Surgery,2004,136(6):1122-1128.
- 5Ahmed MI,Salahy EE,Tawfiq H.Matrix metalloproteinase,squa-mous cell carcinoma antigen,and tissue polypeptide specific antigen expression in Egyptian patients with cervical carcinoma;relationship with prognosis[J],Dis Markers,2004,20(6):333-343.
- 6Oyama T,Osaki T,Baba T.Molecular genetic tumor markers in non-small cell lung cance[J].Anticancer Res,2005,25(2B):1193-1196.
- 7王更记,张芊,宋现让.肺癌肿瘤标志物研究进展[J].齐鲁医学检验,2004,(6):15-17.
- 8王国洪,万文微,刘波,等四种肿瘤标志物检测非小细胞肺瘤的临床应用研究[J].中华检验医学杂志,2003,26(8):491-494.
- 9Schneider J,Velcovsky HG,Katx N,et al.Comparison of the tumer marker N2-PK,CEA,CYFRA211,NSE and SCC in the diagnosis of lung cancer[J].Anticancer Res,2000,20(6D):5053-5058.