甘露糖基糖蛋白N-乙酰氨基葡萄糖转移酶在恶性肿瘤中作用的研究进展
杜俊;闫文武;汪进国;
摘要(Abstract)：
蛋白质糖基化是糖基转移酶将糖基供体转移到糖基接受体上的过程,恶性肿瘤中常存在异常糖基化的糖蛋白,并且糖基转移酶在其中起到重要作用。催化尿苷二磷酸-N-乙酰氨基葡萄糖(uridine diphospho-N-acetylglucosamine,UDP-GlcNAc)转移到甘露糖基糖蛋白上的N-乙酰氨基葡萄糖转移酶(N-acetylglucosaminyltransferases,GnTs)家族可以调控肿瘤相关N-聚糖的糖基化修饰。GnTs在不同肿瘤组织中的表达与患者临床病理学特征和临床预后密切相关,并且GnTs可能参与肿瘤凋亡,肿瘤增殖、肿瘤免疫、肿瘤耐药和肿瘤转移。本文对GnTs在恶性肿瘤中的最新研究进展进行综述,旨在阐明各GnTs在肿瘤中的表达及肿瘤进展中的具体分子作用机制。
关键词(KeyWords)： N-乙酰氨基葡萄糖转移酶;肿瘤;分子机制
基金项目(Foundation):
作者(Author): 杜俊;闫文武;汪进国;
Email:
DOI: 10.13799/j.cnki.mdjyxyxb.2020.06.026
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