郭建宇;齐宝林;齐晓轩;

• 1:牡丹江医学院
• 2:牡丹江医学院附属红旗医院

摘要(Abstract)：

目的探讨微创和开放肺癌切除术对肺腺癌患者围术期循环肿瘤细胞的影响。方法选择行肺腺癌切除手术患者61例,根据手术方式分为微创肺腺癌切除术组(31例)和开放肺腺癌切除术组(30例),运用免疫磁珠富集法,流式细胞仪检测患者术前3日、术中和术后3日外周血CTCs(circuating tumor cells,CTCs)的含量,比较手术前后上述指标变化,并进行统计学分析。结果 (1)61例肺腺癌患者中,术前3日CTCs检测35例(57.4%)为阳性。(2)61例肺腺癌患者外周血术中CTCs量(5.23±2.31)均高于术前CTCs量(3.43±1.98),术后CTCs量(9.46±3.86)均高于术中(5.23±2.31),差异均有统计学意义(P<0.001)。(3)微创肺腺癌切除术组术前CTCs量(3.42±2.03)和开放肺腺癌切除术组术前CTCs量(3.43±1.96),比较差异无统计学意义(P>0.05);微创肺腺癌切除术组术中CTCs量(5.06±2.35)和开放肺腺癌切除术组术中CTCs量(5.40±2.30),外周血CTCs的水平比较差异无统计学意义(P>0.05);但微创肺腺癌根治术组术后外周血CTCs量(7.58±2.92),显著低于开放手术组(11.40±3.78),差异有统计学意义(P<0.001)。结论微创手术有助于降低术后早期外周血中因手术播散的CTCs量,为术后患者的治疗效果的评估以及临床患者手术方式的选择提供参考。

关键词(KeyWords)： 腺癌;肺腺癌切除术;循环肿瘤细胞

Abstract:

Keywords:

基金项目(Foundation): 牡丹江医学院研究生创新项目(2018YJSCX-22MY);; 黑龙江省省属高等学校基本科研业务费科研项目(2018-KYYWT-MY-0075)

作者(Author): 郭建宇;齐宝林;齐晓轩;

Email:

DOI: 10.13799/j.cnki.mdjyxyxb.2020.03.030

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