结肠癌MMP-9和nm23表达的相关性研究THE CORRELATION OF EXPRESSION OF MMP-9 AND NM23 IN COLORECTAL CARCIINOMA
曹永;高唐鑫子;杨静;孙超;张荣;欧阳苏珊;王钊;李凤英;李恒柱;于建渤;李志强;张晓莉;
摘要(Abstract)：
目的:研究MMP-9和nm23在结肠癌中的表达及其与侵袭转移之间的关系,探讨MMP-9与nm23之间的相关性。方法:采用免疫组化SP法对41例结肠癌和5例正常结肠组织做MMP-9和nm23的抗原标记。结果:MMP-9和nm23的表达与淋巴结转移、分化程度、Duke’s分期有明显相关性(P<0.01);MMP-9和nm23的表达与结肠癌患者年龄、性别有明显相关(P<0.01);MMP-9与nm23在结肠癌的表达无相关性。结论:MMP-9和nm23的表达与结肠癌侵袭转移密切相关,可作为判断结肠癌预后的指标。。
关键词(KeyWords)： 基质金属蛋白酶9;转移抑制基因23;侵袭;转移
基金项目(Foundation): 黑龙江省新世纪高等教育教学改革工程项目
作者(Authors): 曹永;高唐鑫子;杨静;孙超;张荣;欧阳苏珊;王钊;李凤英;李恒柱;于建渤;李志强;张晓莉;
DOI: 10.13799/j.cnki.mdjyxyxb.2010.02.048
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