FAK、INTβ_1在动脉粥样硬化的表达及意义THE EXPRESSION OF THE FAK AND INTEGRINβ_1 IN PLAQUE OF ATHEROSCLEROSIS MODEL
李志强;郑慧哲;展涛;颜彬;王宏伟;
摘要(Abstract)：
目的:观察FAK、INTβ1在动脉粥样硬化(AS)斑块中的表达,探讨其在AS形成和发展过程中所起的作用。方法:将40只健康雄性新西兰白兔随机分为三组:(1)空白对照组(正常组)8只,喂基础饲料;(2)阳性对照组(模型组)16只,高脂高胆固醇饲料喂养;(3)木耳多糖组(预防组)16只,每天每兔给高脂高胆固醇饲料+5g木耳多糖喂养。12周末所有实验用兔麻醉处死,行主动脉粥样硬化病理形态学观察。通过HE染色、免疫组织化学染色对斑块内的病变进行定位、定量分析。结果:FAK、INTβ1在正常组呈弱阳性表达,而在模型组和预防组中血管内膜和中膜呈阳性表达。预防组与模型组对照的结果显示,FAK、INTβ1在预防组中的表达较模型组明显减少。结论:AS发生发展过程中存在FAK、INTβ1的异常表达。INTβ1-FAK信号转导通路可能在动脉粥样硬化发生发展过程中起重要作用。
关键词(KeyWords)： 动脉粥样硬化;整合素;粘着斑激酶;木耳多糖;斑块;血管平滑肌细胞
基金项目(Foundation): 黑龙江省教育厅科学技术研究项目(11521335)
作者(Authors): 李志强;郑慧哲;展涛;颜彬;王宏伟;
DOI: 10.13799/j.cnki.mdjyxyxb.2009.05.025
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