Bcl-2家族对肝细胞癌凋亡及自噬作用的研究进展
李尧;张展;赵雅婷;易江南;王乔艳;冯华;
摘要(Abstract):
肝细胞癌是世界范围内一种严重危害人类健康的多发性恶性肿瘤。随着对其研究的深入,发现Bcl-2家族不仅对肝癌细胞的凋亡具有双向调控作用,还参与到肝癌细胞的自噬过程,甚至对于肝细胞癌的诱发因素,如肝硬化、慢性肝炎等也具有调控作用。由于Bcl-2家族内部成员之间对肝细胞癌的调控存在着错综复杂的联系,故本文就Bcl-2家族在肝癌细胞的凋亡及自噬过程中所发挥的作用做一综述。
关键词(KeyWords): 肝细胞癌;Bcl-2家族;凋亡;自噬
基金项目(Foundation): 牡丹江医学院学生科研立项项目(201904);; 黑龙江省大学生创新创业训练计划项目(201910229062)
作者(Authors): 李尧;张展;赵雅婷;易江南;王乔艳;冯华;
DOI: 10.13799/j.cnki.mdjyxyxb.2020.03.037
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