郑俊雅;张珍;李鲁新;段新鹏;

• 1:牡丹江医学院

摘要(Abstract)：

急性肺损伤/急性呼吸窘迫综合征(acute lung injury/acute respiratory distress syndrome, ALI/ARDS)是一类严重危害人类健康的全球性医学问题。ALI/ARDS是以肺水肿为主要特征的疾病,其发病机制是由于肺血管通透性增加,导致水肿液形成并积聚在肺泡腔和肺间质。钠离子的转运形成的渗透压梯度会影响肺泡腔内液体的吸收,所以上皮钠通道(epithelial sodium channel,ENaC)所介导的钠离子的转运在肺水肿形成过程中起到十分重要的作用。细胞因子诱导的炎症反应可能对肺部钠离子转运产生直接或间接的影响。因此本文对近年来局部细胞因子在调节ENaC通道所介导的肺泡液体转运方面研究进展进行了简要的综述。

关键词(KeyWords)： 上皮钠通道;急性肺损伤;细胞因子

Abstract:

Keywords:

基金项目(Foundation): 牡丹江医学院研究生创新科研项目(2017YJSCX-15MY)

作者(Authors): 郑俊雅;张珍;李鲁新;段新鹏;

DOI: 10.13799/j.cnki.mdjyxyxb.2019.04.040

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