钙敏感受体与癌症关系的研究进展
李姝;董琦;孙健;陈彻;
摘要(Abstract):
钙敏感受体(Ca SR)是一种广泛表达的G蛋白偶联受体,对机体维持Ca2+平衡起到关键作用。同时也参与细胞增殖、分化、凋亡、基因表达、离子通道开关、衰老等过程的调控。目前研究表明多种癌症的发生与Ca SR的表达异常有着密切的联系。对Ca SR信号的更深入的研究,将有助于开发以Ca SR或其配体为靶点的新型抗癌药物。
关键词(KeyWords): Ca SR;癌症;研究进展
基金项目(Foundation): 黑龙江省教育厅科学技术研究项目(12531749)
作者(Authors): 李姝;董琦;孙健;陈彻;
DOI: 10.13799/j.cnki.mdjyxyxb.2016.05.050
参考文献(References):
- [1]景坤玉,董腾慧,郭明洲,等.食管鳞状细胞癌细胞及组织中钙敏感受体基因启动子区甲基化状态检测[J].郑州大学学报(医学版),2013,2:155-159.
- [2]BROWN E M,GAMBA G,RICCARDI D,et al.Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid.Nature,1993,366(6455):575-580.
- [3]徐灵驰.背根神经节中神经元钙敏感蛋白VILIP-1上调P2X3受体促使大鼠骨癌痛发生[J].中国疼痛医学杂志,2013,10:621.
- [4]SARAH C,BRENNAN,URSULA T,et al.Calcium sensing receptor signalling in physiology and cancer[J].Biochimica et Biophysica Acta 2013,1833:1732-1744.
- [5]杨睿,姜文波,孟庆威.钙敏感受体和E钙粘蛋白在肺腺癌中的表达及其临床意义[J].临床与病理杂志,2015,8:1504-1510.
- [6]崔恺麟,吴冰霞,李波,等.钙敏感受体在非小细胞肺癌中的表达及临床病理意义[J].中国医药导报,2015,1:27-29.
- [7]毕海量,孙轶华.钙敏感受体在细胞凋亡过程中的作用[J].临床检验杂志,2015,9:703-704.
- [8]CHLEBOWSKI R T,JOHNSON K C,KOOPERBERG C,et al.Calcium plus vitamin D supplementation and the risk of breast cancer[J].Journal of the National Cancer Institute,2008,100(22):1581-1591.
- [9]孙永森.山羊钙敏感受体(Ca SR)基因对乳腺上皮细胞钙代谢的分子调控研究[D].西北农林科技大学,2014.
- [10]叶俊.血中维生素D、血钙浓度及钙敏感受体与乳腺癌的相关性研究[D].南华大学,2014.
- [11]EL H Y,LEHEN’KYI V,OUADID-AHIDOUCH H,et al.Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1cation channel overexpression potentially through EGFRpathways[J].Archives of biochemistry and biophysics,2009,486(1):58-63.
- [12]LIAO J,SCHNEIDER A,DATTA N S,et al.Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis[J].Cancer Res,66(2006):9065–9073.
- [13]马艳波,赵浩亮,刘建生.原发性甲状旁腺功能亢进症的临床特点与外科治疗[J].山西医药杂志,2008,37(6):547-548.
- [14]HAVEN C J,VAN PUIJENBROEK M,KARPERIEN M,et al.Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma[J].The Journal of pathology,2004,202(1):86-94.
- [15]KOH J,DAR M,UNTCH B R,et al.Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor[J].Molecular endocrinology,2011,25(5):867-876.
- [16]CORBETTA S,ELLER V C,VICENTINI L,et al.Modulation of cyclin D1 expression in human tumoral parathyroid cells:effects of growth factors and calcium sensing receptor activation[J].Cancer letters,2007,255(1):34-41.
- [17]秦雪玲,宋扬,周晓彬,等.青岛居民矿物质摄入量对结直肠肿瘤发生的影响[J].齐鲁医学杂志,2012,27(3):199-201.