单二波;于园园;张杰;

• 1:蚌埠医学院第二附属医院普外科

摘要(Abstract)：

目的探究大蒜摄入与人群结直肠癌(colorectal/colon/rectal cancer,CRC)发病风险之间的关系。方法检索数据库PubMed、Web of Science、Embase和CNKI,搜索大蒜摄入与CRC发病风险相关的队列研究和病例对照研究。通过纳入与排除标准筛选符合要求的文献,然后提取相关数据,在Stata软件中进行meta分析,探究大蒜摄入与CRC发病风险之间的关系。结果本研究共纳入研究14篇,包括7项队列研究和7项病例对照研究。分析结果显示,大蒜低、中等及高摄入组合并效应量ES及95%置信区间(confidence interval,CI)分别为0.82(95%CI:0.773⁰.867),0.625(95%CI:0.5940.867),0.625(95%CI:0.594⁰.655)及0.321(95%CI:0.2970.655)及0.321(95%CI:0.297⁰.345)(P<0.05),女性组合并效应量ES=1.188(95%CI:1.090.345)(P<0.05),女性组合并效应量ES=1.188(95%CI:1.09¹.286)(P<0.05)。结论大蒜摄入可以明显降低CRC患病风险。而在相同修正因素下,男性患CRC风险的降低较女性显著。

关键词(KeyWords)： 大蒜;结直肠癌;荟萃分析

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 单二波;于园园;张杰;

DOI: 10.13799/j.cnki.mdjyxyxb.2017.05.004

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