肝细胞癌发病机制的研究进展
冯华;任春慧;王凤爽;
摘要(Abstract)：
肝细胞癌(HCC)的发病机制目前仍不清楚,但HBV感染是引起HCC的重要因素之一,而HBX又是HBV复制和扩散所必须的基因。在肝细胞癌的发生中具有重要作用。X蛋白具有多种生物学功能,并在HCC的发生中参与了多条途径。DNA甲基化也是目前肿瘤发病机制研究中的热点,特别是抑癌基因的异常甲基化,在肝细胞癌的诊断、疗效、预后判断及治疗等方面发挥着重要作用。本文就HBX及HCC相关基因的异常甲基化在HCC发生中的几种可能作用机制作一综述。
关键词(KeyWords)： 肝细胞癌;HBX;DNA甲基化
基金项目(Foundation):
作者(Authors): 冯华;任春慧;王凤爽;
DOI: 10.13799/j.cnki.mdjyxyxb.2007.04.058
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