吴红;念红;吴琦;吴宜艳;刘桂莲;李伟阳;董凯;

• 1:牡丹江医学院

摘要(Abstract)：

目的:观察银杏叶提取物(GBE)对大鼠肝细胞色素P450酶系统中CYP2D6活性的影响。方法:HPLC法测定大鼠尿液和肝微粒体中探针药物右美沙芬的含量。对照组和实验组大鼠分别经口给予生理盐水和银杏叶提取物两周,差速离心分离肝微粒体,HPLC法测定大鼠尿液和肝微粒体中CYP2D6探针药物的代谢率。观察银杏叶提取物对CYP2D6活性的影响。结果:实验组大鼠给予银杏叶提取物(100mg/kg),其尿样中右美沙芬的代谢率与对照组相比没有明显差别(P>0.05);实验组大鼠肝微粒体中加入右美沙芬(0.324mmol/L),其右美沙芬的代谢率与对照组相比没有明显差别(P>0.05);银杏叶提取物没有明显降低右美沙芬的代谢率(P>0.05)。结论:银杏叶提取物对CYP2D6酶无明显影响。

关键词(KeyWords)： 银杏叶提取物;肝微粒体;CYP2D6

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省自然基金科研项目D2007104;; 黑龙江省卫生厅科研项目2006393

作者(Authors): 吴红;念红;吴琦;吴宜艳;刘桂莲;李伟阳;董凯;

DOI: 10.13799/j.cnki.mdjyxyxb.2010.01.007

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