远端缺血后处理缓解缺血再灌注损伤的研究进展
马丽丽;张冰缘;王济涛;苏艾中;
摘要(Abstract)：
远端缺血后处理是近年提出的减少器官组织缺血再灌注损伤的新理论、新方法。其作用机制复杂涉及氧自由基、腺苷、一氧化氮等启动因子,各种细胞信号转导通路以及最终效应器线粒体等,具有减少再灌注损伤、改善器官功能的作用,在器官移植、心脏手术、脑卒中治疗等领域有巨大的临床应用价值。
关键词(KeyWords)： 远端缺血后处理;缺血再灌注损伤;机制;临床应用
基金项目(Foundation):
作者(Authors): 马丽丽;张冰缘;王济涛;苏艾中;
DOI: 10.13799/j.cnki.mdjyxyxb.2017.04.041
参考文献(References)：
- [1]MURRY C E,JENNINGS R B,REIMER K A.Preconditioning with ischemic:a delay of lethal cell injury in ischemic myocardium[J].Circulation,1986,74(5):1124-1136.
- [2]PRZYKLENK K,BAUER B,OVIZE M,et al.Regional ischemic preconditioning protects remote virgin myocardium from subsequent sustained coronary occlusion[J].Cricluation,1993,87(3):893-899.
- [3]ZHAO Z Q,CORVERA J S,HALKOS M E,et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning[J].Am J Physiol Heart Circ Physiol,2003,285:579-588.
- [4]KERENDI F,KIN H,HALKOS M E,et al.Brief renal ischemia and reperfusion applied beford coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors[J].Basic Res Cardiol,2005,100(5):404-412.
- [5]GYURKOVICS E,ARANYI P,STANGL R,et a1.Postconditioning of the lower limb pro tecti-on against the reperfusion syndrome[J].Surg Res,2011,169(1):139-147.
- [6]吴卫娟,孟然.远隔缺血后处理脑保护的研究进展[J].中华老年心血管病志,2016,18(9):1003-1005.
- [7]PENG B,GUO Q L,HE Z J.et al.Remote ischemic postconditioning protects the brain from global cerebral ischemic/reperfusion injury by up-regulating endothelial nitric oxide synthase through the P13K/AKT pathway[J].Brain Res,2012,1445:92-102.
- [8]XU Y C,XUE F S,LIAO X,et al.Remote preconditioning,endogenous cardiopretection from outside the heart[J].Anesth Resus,2012,33(4):275-279,291.
- [9]GNLATL P,SINGH N.Neuroprotectlve mechanism of ischemic postconditioning in mice:a possible relationship between prorein kinase C and nitric oxide pathways[J].Surg Res,2014,89:174-183.
- [10]LIU X W,JI E F,HE P,et al.Protective effects of the p38 MAPK inhibitor SB203580 on NMDA induces injury in primary cerebral cortical neurous[J].Mol Med Rep,2014,10(4):1942-1948.
- [11]LI H,ZHOU S,WU L,et al.The role of p38MAPK signal pathway in the neuroprotective mechanism of limb postconditioning against rat cerebral ischemia/reperfusion inj ury[J].Neurol Sci,20l5,357:270-275.
- [12]薛富善,杨桂珍,刘高谱.缺血预处理和后处理减轻缺血/再灌注损伤的分子机制[J].国际麻醉学与复苏杂志,2016.37(1):72-76.
- [13]韦家俊,李浩,廖小明,等.JAK2-STAT3通路介导肢体缺血后处理脑缺血再灌注损伤保护作用的研究[J].安徽医科大学学报,2014,49:1714-1717.
- [14]OBAL D,DETTWILER S,FAVO C.The influence of mitochondrial KATP channels in thne cardioprotection of preconditioning and postconditioning by wevoflur-ane in the rat in vivo[J].Anesth Analg,2005,101(11):1252-1256.
- [15]KALOGERIS T,BAINES C P,KRENZ M,et a1.Cell biologyof ischemia/reperfusion injury[J].Int Rev Cell Mol Biol,2012,298:229-317.
- [16]XU Y C,XUE F S,LIAO X,et a1.Remote preconditioning,endogenous cardiopret-ection from outside the heart[J].Anesth Resus,2012,33(4):275-279,291.
- [17]LIM S Y,DAVIDSON S M,HAUSENLOY D J,et al.Preconditoning and postconditioning:the essential role of the mitochondrial permesbility transition pore[J].Cardiovasc Res,2007,75(3):530-535.
- [18]BOENGLER K,HILFIKER D.Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in muocardial ischemia/reper-fusion[J].Basic Res Catdiol,2010,105(6):771.
- [19]SUN J,LUAN Q,DONG H,et al.Inhibition of mitochondrial permesbility transi-tion pore opening contributes to the neuroprotective effects of ischemic postconditioning in rats[J].Brain Res.2012,1436:101-110.
- [20]STAAT P,RIOUFOL G,PIOT C,et al.Postconditioning the human heart[J].Circulation,2005,112(14):2143-2148.
- [21]CARCIA S,HENRY T D,WANG Y L,et al.Long-term followup of patients undetgoing postconditionging during ST-elevation myocardial infarction[J].Catdiovasc Transl Res,2011,4(1):92-98.
- [22]HOUGAARD K D,HJORT N,ZEIDLER D,et a1.Remote iscbemic perconditioning in thrombolysed stroke patients:randomized study of activating endogenous neuroprotection-design and MRI measurements[J].Stroke,2013(8):141-146.
- [23]孟明,孙茂林,王薇,等.肢体远端缺血后处理对急性脑梗死患者血清谷氨酸浓度影响的临床观察[J].临床好实验医学杂志.2016.15(9):841-842.
- [24]PAN J,I.I X,PENG Y.Remote ischemic conditioning for acute ischemic stroke:dawn in the darkness[J].Rev Neurosci,2016,27:501-510.