郑慧哲;黄康;范宏芳;岳慧轩;华长星;曹永;于建渤;

• 1:牡丹江医学院病理教研室
• 2:牡丹江医学院

摘要(Abstract)：

结肠癌和胃癌的浸润生长和远处转移是患者死亡的重要因素,关于胃癌和结肠癌的发生发展机制尚不清楚。近年研究发现趋化因子及其受体不仅在炎症过程中有重要作用,在胃肠癌的发生发展中亦发挥着重要的作用,其可能在肿瘤细胞侵袭转移的过程中起着诱导和趋化的作用。趋化因子和其受体可能成为将来胃肠癌治疗的一个新靶点。

关键词(KeyWords)： 趋化因子;结肠癌;胃癌;转移;侵袭

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省高等教育教学改革项目(JGZ2012012817);; 牡丹江医学院大学生科研项目(201128)

作者(Authors): 郑慧哲;黄康;范宏芳;岳慧轩;华长星;曹永;于建渤;

DOI: 10.13799/j.cnki.mdjyxyxb.2015.02.037

参考文献(References)：

• [1]Han TT,Fan L,Li JY,et al.Role of chemokines and their receptors in chronic lymphocytic leukemia:function in microenvironment and targeted therapy[J].Cancer Biol Ther,2014,15(1):3-9.
• [2]Viola A,Sarukhan A,Bronte V,et al.The pros and cons of chemokines in tumor immunology[J].Trends Immunol,2012,33(10):496-504.
• [3]Zlotnik A,Yoshie O,Nomiyama H.The chemokine and chemokine receptor superfamilies and their molecular evolution[J].Genome Biol,2006,7(12):243.
• [4]余力伟,马向涛,王杉,等.趋化因子受体CCR6/CCL20信号转导通路与胃癌淋巴结转移[J].北京医学,2007,29(11):644-646.
• [5]Yu JB,Zhang YC,Yang QP,et al.Invasion-associated genes identified by gene expression profiling in extranodal natural killer/T-cell lymphoma,nasal type[J].Leuk Lymphoma 2013,54(1):90-98.
• [6]郭晓临,王立娥,李莉,等.白细胞介素-8在胃癌组织中的表达及意义[J].实用肿瘤学杂志,2001,15(4):255-256.
• [7]贾忠,贺冠海,封光华,等.趋化因子L-8与胃癌组织中侵润炎性细胞相关性分析[J].J Med Res,2007,36(2):42-44.
• [8]赵金伟,王钟林,马震,等.术前镜检标本VEGF-C和CCR7表达预测胃癌淋巴结转移的临床研究[J].中国实验诊断学,2010,14(7):1049-1050.
• [9]Rubie C,Frick VO,Pfeil S,et al.Correlation of IL-8 with induction,progression and metastatic potential of colorectal cancer[J].World J Gastroenterol,2007,13(37):4996-5002.
• [10]Rubie C,Frick VO,Ghadjar P,et al.Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases[J].World J Gastroenterol,2011,17(26):3109-3116.
• [11]Sugasawa H,Ichikura T,Tsujimoto H,et al.Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer[J].J Surg Oncol,2008,97(5):445-450.
• [12]Lee JH,Cho YS,Lee JY,et al.The chemokine receptor CCR4is expressed and associated with a poor prognosis in patients with gastric cancer[J].Ann Surg,2009,249(6):933-941.
• [13]赵金伟,王广义,孙明.趋化因子受体CCR7在胃癌及转移淋巴结中的表达及其意义[J].Chin J Lab Diagn,2007,11(4):46-48.
• [14]Schmausser B,Endrich S,Brandlein S,et al.The chemokine receptor CCR7 is expressed on epithelium of non-inflamed gastric mucosa,Helicobacter pylori gastritis,gastric carcinoma and its precursor lesions and up-regulated by H.pylori[J].Clin Exp Immunol,2005,139(2):323-327.
• [15]Yan C,Zhu ZG,Yu YY,et al.Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis[J].World J Gastroenterol,2004,10(6):783-790.
• [16]Mashino K,Sadanaga N,Yamaguchi H,et al.Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma[J].Cancer Res,2002,62(10):2937-2941.
• [17]孙仁虎,王国斌,李疆,等.CCL21在人结肠癌SW480细胞侵袭过程中的作用[J].癌症,2009,28(7):708-713.
• [18]Yasumoto K,Koizumi K,Kawashima A,et al.Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer[J].Cancer Res,2006,66(4):2181-2187.
• [19]Ishigami S,Natsugoe S,Okumura H,et al.Clinical implication of CXCL12 expression in gastric cancer[J].Ann Surg Oncol,2007,14(11):3154-3158.
• [20]Ottaiano A,Franco R,Aiello TA,et al.Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients[J].Clin Cancer Res,2006,12(9):2795-2803.
• [21]Futagami S,Tatsuguchi A,Hiratsuka T,et al.Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase up regulation in gastric cancer[J].J Gastroenterol,2008,43(3):216-224.
• [22]Eck M,Schmausser B,Scheller K,et al.Pleiotropic effects of CXC chemokines in gastric carcinoma:differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma[J].Clin Exp Immunol,2003,134(3):508-515.
• [23]Roy I,Evans DB,Dwinell MB.Chemokines and chemokine receptors:update on utility and challenges for the clinician[J].Surgery,2014,155(6):961-973.