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帕金森病(parkinson disease, PD)是最常见的神经退行性运动障碍疾病，其病因目前尚未完全明确，主要病理特征为错误折叠的α-突触核蛋白(α-synuclein, α-syn)沉积及多巴胺能神经元的异常丢失，PD运动症状主要包括静止性震颤、运动迟缓、异常步态等。脑血管周围间隙(perivascular space, PVS)又称Virchow-Robin间隙是指围绕在脑小血管周围的间隔组织，是脑脊液循环及清除脑内的代谢废物的重要场所，PVS有助于清除脑内异常的α-syn及多巴胺能神经元产生的代谢废物。脑血管周围间隙扩大(enlarged perivascular space, EPVS)的机制尚未完全阐明，但经研究证实，PVS清除率下降或异常成分过度沉积可能是导致EPVS的机制之一。EPVS与多种神经系统疾病相关，近几年研究发现EPVS与PD伴随运动症状的发生发展密切相关，本文就EPVS与PD伴随运动症状的相关性研究进展进行综述。
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基本信息:
DOI：10.13799/j.cnki.mdjyxyxb.2024.01.013
中图分类号:R742.5
引用信息:
[1]吕坤雪,贾正兴,崔耀月,等.帕金森病伴运动症状与血管周围间隙扩大相关性的研究进展[J].牡丹江医学院学报,2024,45(01):129-132.DOI:10.13799/j.cnki.mdjyxyxb.2024.01.013.
基金信息:
黑龙江省卫生健康委科技计划项目(20220909010679); 黑龙江省省属高等学校基本科研业务费科研项目(2021-KYYWF-0507)
2024-02-06
2024-02-06