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目的 系统评价儿童糖尿病酮症酸中毒并发脑水肿的危险因素。方法 计算机检索CNKI、VIP、Wang Fang Data、CBM、PubMed、Web of Science、Cochrane Library、Embase、CINAHL有关儿童糖尿病酮症酸中毒并发脑水肿危险因素的研究，检索时限均为建库至2024年11月17日，两名独立的研究人员进行文献筛选与信息提取工作，采用Stata 18.0软件进行Meta分析。结果 共纳入14篇文献，总样本量为9 791例。影响因素结果显示，血尿素氮越高(OR=1.935,95%CI:1.385～2.702)、血钠越低(OR=1.740,95%CI:1.254～2.413)、碳酸氢盐越高(OR=2.240,95%CI:1.938～2.589)、pH值越低(OR=2.111,95%CI:1.677～2.657)、新发糖尿病(OR=3.327,95%CI:1.777～6.226)和年龄≤3岁(OR=2.457,95%CI:1.113～5.424)是儿童糖尿病酮症酸中毒并发脑水肿的危险因素。结论 影响儿童糖尿病酮症酸中毒并发脑水肿的危险因素较多，应针对以上危险因素制定更为精准的预防和治疗策略，以降低脑水肿发生的风险，保障患儿的健康与安全。
Abstract：Objective To systematically evaluate the risk factors of diabetic ketoacidosis complicated with cerebral edema in children.Methods A computer search was conducted on CNKI,VIP,Wang Fang Data, CBM,PubMed, Web of Science, Cochrane Library, Embase, and CINAHL for studies on the risk factors of pediatric diabetic ketoacidosis complicated with cerebral edema.The search period spanned from the inception of the databases up to November 17,2024.Two independent researchers performed literature screening and information extraction, and Stata 18.0 software was utilized for meta-analysis.Results A total of 14 articles were included, with a total sample size of 9 791 cases.The results of influencing factors showed that the higher the blood urea nitrogen(OR=1.935,95%CI: 1.385-2.702),the lower the blood sodium(OR=1.740,95%CI:1.254-2.413) and the higher the bicarbonate(OR=2.240,95%CI:1.938-2.589),lower pH value(OR=2.111,95%CI: 1.677-2.657),new onset diabetes(OR=3.327,95%CI: 1.777-6.226) and age ≤3 years(OR=2.457,95%CI: 1.113-5.424) were risk factor for pediatric diabetic ketoacidosis complicated with cerebral edema.Conclusion There are multiple risk factors influencing children with diabetic ketoacidosis complicated by cerebral edema, and more accurate prevention and treatment strategies should be developed based on these risk factors to reduce the risk of cerebral edema and ensure the health and safety of children.
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基本信息:
DOI：10.13799/j.cnki.mdjyxyxb.2025.04.038
中图分类号:R725.8
引用信息:
[1]王智,王芳,樊冰心,等.儿童糖尿病酮症酸中毒并发脑水肿危险因素的Meta分析[J].牡丹江医科大学学报,2025,46(04):10-14+18.DOI:10.13799/j.cnki.mdjyxyxb.2025.04.038.
基金信息:
广安市科技创新项目(2024CG02); 成都中医药大学附属医院科研项目(WXLH202403180)
2025-01-07
2025
2025-04-08
2025-02-25
2025
1
2025-08-15
2025-08-15