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2025, 06, v.46 142-145
miRNA对卵巢癌侵袭、迁移及EMT影响的研究进展
基金项目(Foundation): 牡丹江医科大学大学生科研立项项目(2025003); 黑龙江省卫生健康委科研课题(20230202060133); 牡丹江医学院博士科研启动基金项目(2022-MYBSKY-007); 黑龙江省省属高等学校基本科研业务费科研项目(2023-KYYWFMY-0004)
邮箱(Email):
DOI: 10.13799/j.cnki.mdjyxyxb.2025.06.006
摘要:

卵巢癌(Ovarian cancer,OC)是危害女性健康的常见恶性肿瘤之一,其侵袭、转移迅速,大多数患者确诊时已是晚期,且治疗效果不佳,治疗过程中易产生耐药,亟待寻找新的治疗手段。微小RNA(microRNA,miRNA ),是一类含有22~24个核苷酸的内源性非编码单链小分子RNA,miRNA通过与下游靶基因mRNA结合,调控蛋白质的表达,进而参与细胞正常生理功能的调节及肿瘤的发生和发展。通过对miRNA的研究,有助于了解miRNA在卵巢癌发生发展中的作用、改进治疗方案、研发靶向药物以及突破治疗耐药等。大量研究揭示了miRNA在OC侵袭、迁移及上皮-间充质转化(epithelial-mesenchymal transition,EMT)相关的的作用机制。本文对近年来miRNA在调节OC侵袭、迁移及EMT等方面的研究进展进行综述,为OC的早期诊断及精准治疗提供思路及理论依据。

Abstract:

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参考文献

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基本信息:

DOI:10.13799/j.cnki.mdjyxyxb.2025.06.006

中图分类号:R737.31

引用信息:

[1]马靖超,薛宝珠,王冠宇,等.miRNA对卵巢癌侵袭、迁移及EMT影响的研究进展[J].牡丹江医科大学学报,2025,46(06):142-145.DOI:10.13799/j.cnki.mdjyxyxb.2025.06.006.

基金信息:

牡丹江医科大学大学生科研立项项目(2025003); 黑龙江省卫生健康委科研课题(20230202060133); 牡丹江医学院博士科研启动基金项目(2022-MYBSKY-007); 黑龙江省省属高等学校基本科研业务费科研项目(2023-KYYWFMY-0004)

投稿时间:

2025-08-07

投稿日期(年):

2025

终审时间:

2025-11-26

终审日期(年):

2025

审稿周期(年):

1

发布时间:

2025-12-15

出版时间:

2025-12-15

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